Cytotoxicity of heated chrysotile

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Cytotoxicity of heated chrysotile

Cytotoxicity and hemolysis were studied in chrysotile and quartz. The biological activity of the surface seemed to be different between chrysotile and quartz. Quartz lost its cytotoxicity on heating over about 500 degrees C. However chrysotile showed remarkable toxicity and induced hemolysis on heating between 650 and 800 degrees C, compared with the original unheated specimens. The mice inject...

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Thermal modification of chrysotile asbestos: evidence for decreased cytotoxicity.

Many asbestiform minerals exhibit temperature-dependent thermoluminescence. Since thermoluminescence involves electronic transitions within crystalline materials, the effect of temperature on asbestos cytotoxicity was evaluated. Heat pretreatment of Canadian chrysotile asbestos reduces its cytotoxicity towards cultured human fibroblasts and bovine alveolar macrophages. When monitored 44 hr afte...

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Some observations on the in vitro cytotoxicity of chrysotile prepared by the wet dispersion process.

Samples of the chrysotile taken during and after treatment by the wet dispersion process have been tested for their cytotoxic effect in vitro and the results compared with both a UICC chrysotile A sample and a dust prepared from a standard chrysotile textile yarn. Results were obtained from three different in vitro assay systems utilizing P388D1, V79-4 and A549 cells. A sample which still conta...

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Cytotoxicity and multinucleate giant cell formation in Chinese hamster lung fibroblast caused by crocidolite and chrysotile.

The mechanism of carcinogenic action of asbestos remains unclear but the physical properties of the fiber appear to be important in this process. Asbestos may cause multinucleate giant cell formation primarily by interfering with the normal course of mitosis. We evaluated the cytotoxicity and multinucleate giant cell formation induced by crocidolite and chrysotile in Chinese hamster lung fibrob...

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Effects of chrysotile and acid-treated chrysotile on macrophage cultures.

Beck, E. G., Holt, P. F., and Nasrallah, E. T. (1971). Brit. J. industr. Med., 28, 179-185. Effects of chrysotile and acid-treated chrysotile on macrophage cultures. The addition of chrysotile asbestos to monolayer cultures of peritoneal and alveolar macrophages produces an increase in membrane permeability, as measured by eosin uptake and lactic dehydrogenase activity of the supernatant fluid....

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1974

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.749267